Fatty
liver, also known as fatty liver disease (FLD), is a reversible
condition wherein large vacuoles of triglyceride fat accumulate in liver
cells via the process of steatosis (i.e., abnormal retention of lipids
within a cell). Despite having multiple
causes, fatty liver can be considered a single disease that occurs
worldwide in those with excessive alcohol intake and the obese (with or
without effects of insulin resistance). The condition is also associated
with other diseases that influence fat metabolism.[1] It is difficult
to distinguish alcoholic FLD from nonalcoholic FLD, and both show
microvesicular and macrovesicular fatty changes at different stages.
Accumulation of fat may also be accompanied by a progressive inflammation of the liver (hepatitis), called steatohepatitis. By considering the contribution by alcohol, fatty liver may be termed alcoholic steatosis or nonalcoholic fatty liver disease (NAFLD), and the more severe forms as alcoholic steatohepatitis (part of alcoholic liver disease) and Non-alcoholic steatohepatitis (NASH).
Accumulation of fat may also be accompanied by a progressive inflammation of the liver (hepatitis), called steatohepatitis. By considering the contribution by alcohol, fatty liver may be termed alcoholic steatosis or nonalcoholic fatty liver disease (NAFLD), and the more severe forms as alcoholic steatohepatitis (part of alcoholic liver disease) and Non-alcoholic steatohepatitis (NASH).
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